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Iran Strikes Prince Sultan Air Base in Saudi Arabia, Wounding 15 American Soldiers in Biggest Direct U.S. Casualty Attack of the War

Five of the wounded are in serious condition after an Iranian missile or drone hit the base 75 miles southeast of Riyadh, as Houthi rebels simultaneously fired ballistic missiles at Israel for the first time, marking a dramatic single-day escalation.

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Iran Strikes Prince Sultan Air Base in Saudi Arabia, Wounding 15 American Soldiers in Biggest Direct U.S. Casualty Attack of the War

Iran struck the Prince Sultan Air Base in Saudi Arabia on Friday with what U.S. defense officials described as a ballistic missile or drone attack, wounding at least 15 American military personnel in the most direct and significant Iranian strike on U.S. forces since the war began on February 28 — a development that has sharply escalated tension between Washington and Tehran and raised new questions about whether the conflict could draw Saudi Arabia more directly into the fighting.

The Pentagon confirmed that twelve to fifteen service members were wounded in the attack, which struck the base approximately 75 miles southeast of Riyadh. Five of the wounded were described as seriously injured, though none were in life-threatening condition as of late Friday, according to a statement from U.S. Central Command. Prince Sultan Air Base is one of the most significant American military installations in the Middle East, used for logistics, long-range strike operations, and intelligence gathering. Saudi Arabia, which has not formally joined either side of the conflict but has permitted U.S. operations from its territory, condemned the strike as a flagrant violation of international law.

The attack came on the same day that the Houthi movement in Yemen fired its first ballistic missiles at Israel since the U.S.-Israel war on Iran began, targeting sites in southern Israel near Beersheba and Eilat. The twin strikes — one against American forces in Saudi Arabia, one against Israeli territory from Yemen — reflected an expanding arc of proxy warfare that is drawing in more regional actors as the conflict enters its fifth week. U.S. officials have tied the Houthi missile launches directly to Iranian Revolutionary Guard coordination, though Tehran has not publicly confirmed that characterization.

Total U.S. military casualties since the war began now stand at 15 killed and 313 wounded, with the bulk of the wounded occurring in smaller Iranian-coordinated attacks on U.S. positions in Iraq, Syria, and the Persian Gulf region. Congress erupted in debate Friday over the new figures. Senate Armed Services Committee ranking member Jack Reed called for an emergency classified briefing from the Pentagon. Several Republicans called on Trump to escalate air strikes on Iranian military infrastructure in response to the Saudi base attack. Trump posted on social media Friday evening that Iran would pay an extremely high price for the attack, without specifying what action the United States was prepared to take.

The wounding of 15 Americans at a major base on Saudi soil represents an escalation of a different order from earlier proxy strikes on smaller forward positions. Analysts have argued that Iran, facing severe military degradation since the campaign's opening strikes, has shifted its strategy toward attacking the supply chain and logistical backbone of the U.S.-Israel military campaign rather than engaging in direct conventional confrontation. The International Crisis Group issued a statement Saturday urging both sides to pursue the existing diplomatic framework before further escalation leads to a confrontation that draws Saudi Arabia directly into the war — a scenario that would fundamentally alter the scope and scale of the conflict and potentially destabilize the broader Gulf region.

Originally reported by NBC News.

Iran war US troops Saudi Arabia Prince Sultan Air Base casualties Pentagon